Butch Shilton and Joe Peters are on the run and think to hide out in a quiet township. The sheriff finds them on a wanted poster and once again they have to hightail it. Trouble seems to follow the pals and they end up in the confines of the brutal Los Pecos penitentiary. Breaking out they flee over the border into Mexico only to fall foul of the notorious bandit Barka.
They recruit a bunch of escaped prisoners to fight Barka only to find they have make a pact with one set of devils to fight another set of devils. On top of that the prison guards are out scouring the countryside for the escapees. With enemies closing in on all sides there is nowhere to run. Is this the end for Butch and Joe?